全文获取类型
收费全文 | 28385篇 |
免费 | 2416篇 |
国内免费 | 39篇 |
学科分类
医药卫生 | 30840篇 |
出版年
2021年 | 573篇 |
2020年 | 361篇 |
2019年 | 565篇 |
2018年 | 639篇 |
2017年 | 464篇 |
2016年 | 461篇 |
2015年 | 547篇 |
2014年 | 721篇 |
2013年 | 1004篇 |
2012年 | 1465篇 |
2011年 | 1444篇 |
2010年 | 793篇 |
2009年 | 685篇 |
2008年 | 1237篇 |
2007年 | 1303篇 |
2006年 | 1138篇 |
2005年 | 1072篇 |
2004年 | 1117篇 |
2003年 | 993篇 |
2002年 | 937篇 |
2001年 | 888篇 |
2000年 | 889篇 |
1999年 | 736篇 |
1998年 | 368篇 |
1997年 | 340篇 |
1996年 | 301篇 |
1995年 | 311篇 |
1994年 | 217篇 |
1993年 | 189篇 |
1992年 | 622篇 |
1991年 | 551篇 |
1990年 | 523篇 |
1989年 | 504篇 |
1988年 | 498篇 |
1987年 | 443篇 |
1986年 | 478篇 |
1985年 | 477篇 |
1984年 | 371篇 |
1983年 | 310篇 |
1982年 | 214篇 |
1981年 | 201篇 |
1980年 | 210篇 |
1979年 | 355篇 |
1978年 | 236篇 |
1977年 | 220篇 |
1975年 | 190篇 |
1974年 | 232篇 |
1973年 | 210篇 |
1972年 | 204篇 |
1969年 | 203篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
31.
Anti-rheumatic therapy has been targeted against the symptoms arising from chronic inflammation of the joint. This has resulted in the extensive use of non-steroidal anti-inflammatory drugs. It is now becoming apparent that these agents have no beneficial effect on disease progression. This mini review concentrates on the formation and maintenance of pannus, the granulomatous tissue responsible for cartilage and bone erosion. This reveals a number of possible therapeutic targets. Protease inhibitors could be used to interfere with the degradatory processes. The diverse functions of endothelial cells suggest oedema formation, cell accumulation and supply of nutrients to the granulomatous tissue could all be targeted by appropriate therapy. Alternatively the immune processes that control pannus formation and state of activation could be regulated by interfering with antigen presentation and the cytokine network. 相似文献
32.
33.
34.
H. S. Pollinger M. D. Stegall J. M. Gloor S. B. Moore S. R. Degoey N. A. Ploeger W. D. Park H. S. Pollinger M. D. Stegall J. M. Gloor S. B. Moore S. R. Degoey N. A. Ploeger W. D. Park 《American journal of transplantation》2007,7(4):857-863
The immunologic risk associated with donor-specific antibodies (DSA) against Class II human leukocyte antigens (HLA) in kidney transplant (KTx) recipients is unclear. The aim of this study was to determine the outcome of KTx when DSA was detected only against HLA Class II. To isolate the impact of anti-Class II DSA, we retrospectively analyzed 12 KTx recipients who at baseline had a positive B-cell flow cytometric crossmatch (FXM) and a negative T-cell FXM. Using alloantibody specification analysis, 58.3% (7/12) had DSA against donor Class II and 41.7% had no demonstrable DSA. Biopsy-proven AMR occurred in 57% (4/7) in the Class II(+) group and 0% in the Class II(-) group (p > 0.05). Peritubular capillaries stained positive for C4d in 86% (6/7) of the Class II(+) patients and in 40% (2/5) of the Class II(-) patients (p > 0.05). One patient in the Class II(+) group lost their graft at 3 months to accelerated transplant glomerulopathy, while all other grafts were functioning 3-37 months posttransplant despite the persistence of anti-Class II DSA. We conclude that KTx recipients with clearly defined anti-Class II DSA are at risk for humoral rejection suggesting that desensitization and/or close posttransplant monitoring may be needed to prevent AMR. 相似文献
35.
Karen Moore Schaefer 《Rehabilitation nursing》2004,29(2):49-55
Fibromyalgia (FM) is a chronic, potentially disabling, cluster of symptoms that manifests as pain for 3 months or more and pain with pressure on 11 of 18 tender points throughout the body. Because there is no known cause, and therefore, no cure, treatment focuses on the control or relief of symptoms. Many patients are referred to rehabilitation settings for physical or exercise therapy. While exercise is helpful in the control of the pain, stiffness, fatigue, sleep disorders, and mood changes, a holistic approach to treatment is more effective. Rehabilitation nurses provide major support for patients with FM. Validation of the patients' experiences is essential for achieving quality of life. Many patients have a history of being undertreated because of a lack of credibility and invisibility of the illness. This article provides background information about FM, summarizes the FM trajectory, reviews approaches to management, and discusses the role of rehabilitation nurses in a holistic approach to care of clients with FM. 相似文献
36.
37.
39.
40.
Using fura-2 loaded neural tumour cells, SK-N-SH, we demonstrate that receptor-mediated activation of phosphoinositide hydrolysis not only causes the release of Ca2+ from intracellular stores but also causes a concomitant influx of extracellular Ca2+. Thapsigargin (TG), a sesquiterpene lactone, causes a sustained elevation of intracellular Ca2+ and depletion of the inositol 1, 4, 5-trisphosphate-sensitive intracellular Ca2+ stores. In the absence of extracellular Ca2+, the increase in intracellular Ca2+ concentration ([Ca2+]i) was transient, suggesting that thapsigargin activates both intracellular mobilization and the influx of Ca2+ from extracellular space. These results are consistent with the proposal that the depletion of the inositol 1, 4, 5-trisphosphate-sensitive intracellular Ca2+ pool serves as a signal for Ca2+ influx. 相似文献